With the rapid development of electronic technology, a series of headphones with novel shapes and excellent performance have come into the view of the public. In recent years, the public has become increasingly demanding for noise cancellation performance, and the market of ANC headphones has grown rapidly. The increase in demand naturally requires more supply. At the same time, as the traditional ANC headphone testing process is cumbersome, and its operation is difficult and inefficient, the use of efficient automated test methods can improve efficiency significantly. Our ANC headphone auto-calibration test solution cancels the tedious manual gain debugging steps, leads to stable and reliable test results, and reliably ensures the product quality.